Article
[Correlation of genetic polymorphisms in DNA repair genes ADPRT and XRCC1 to risk of gastric cancer].
Ai zheng = Aizheng = Chinese journal of cancer - 1 Jan 2006
Zhang Zhi, Miao Xiao-Ping, Tan Wen, Guo Yong-Li, Zhang Xue-Mei, Lin Dong-Xin
Abstract excerpt
BACKGROUND & OBJECTIVE: Adenosine diphosphate ribosyl transferase (ADPRT) and X-ray repair cross-complementing 1 (XRCC1) are 2 major DNA base excision repair (BER) proteins and act interactively in stimulating and executing BER processes. Polymorphisms of ADPRT 762Val-->Ala and XRCC1 399Arg-->Gln have been verified to associate with altered protein function and BER activity. This study was to examine the...
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