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Autophagy in mycobacterial infections: molecular mechanisms, host-pathogen interactions, and therapeutic opportunities

7 Aug 2025

Abstract excerpt

causing tuberculosis-a leading infectious killer claiming over 1.25 million lives annually-and NTM driving pulmonary and ulcerative infections, particularly in immunocompromised populations. Autophagy, a conserved cellular degradation pathway, serves as a critical mechanism of host defense against mycobacteria by delivering bacteria to the lysosome. As a response, mycobacteria have evolved intricate strategies to...

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PMID: 40851798
DOI: 10.3389/fcimb.2025.1640647

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