Impacts of gene essentiality, expression pattern, and gene compactness on the evolutionary rate of mammalian proteins.

Abstract excerpt

Understanding the determinants of the rate of protein sequence evolution is of fundamental importance in evolutionary biology. Many recent studies have focused on the yeast because of the availability of many genome-wide expressional and functional data. Yeast studies revealed a predominant role of gene expression level and a minor role of gene essentiality in determining the rate of protein sequence evolution....

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