Article
Therapy-related leukemia associated with alkylating agents.
Medical and pediatric oncology - 1 May 2001
Davies S M
Abstract excerpt
The leukemogenic potential of alkylating agents has been known for many years and almost all alkylating agents in clinical use have been shown to increase the risk of leukemia. With these drugs the risk of leukemia appears to increase with increasing patient age, as does the risk of de novo myeloid leukemia in the population. Susceptibility to alkylating agent-associated leukemia is influenced by the genetic...
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