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Mitochondrial DNA mutations in neurodegeneration.

Biochimica et biophysica acta - 1 Nov 2015

Keogh Michael J, Chinnery Patrick F

Abstract excerpt

Mitochondrial dysfunction is observed in both the aging brain, and as a core feature of several neurodegenerative diseases. A central mechanism mediating this dysfunction is acquired molecular damage to mitochondrial DNA (mtDNA). In addition, inherited stable mtDNA variation (mitochondrial haplogroups), and inherited low level variants (heteroplasmy) have also been associated with the development of...

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PMID: 26014345
DOI: 10.1016/j.bbabio.2015.05.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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