Article
Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990
Lazo P A, Lee J S, Tsichlis P N
Abstract excerpt
T-cell lymphomas induced by Moloney murine leukemia virus frequently have proviruses integrated at the Mlvi-4 and Mlvi-1 loci, which map approximately 30 and 270 kilobases 3' of the promoter region of the Myc protooncogene, respectively. Provirus insertion in these loci is responsible for the activation of adjacent genes. To determine whether Myc expression was also affected by these provirus insertions, we...
Topics
- Alleles
- Animals
- Blotting, Northern
- Blotting, Southern
- DNA Transposable Elements
- DNA, Neoplasm
- Gene Expression Regulation, Viral
- Lymphoma
- Poly A
- Promoter Regions, Genetic
- Protein-Tyrosine Kinases