Monoclonal antibody-selected variants of MHV-4 contain substitutions and deletions in the E2 spike glycoprotein.

doi:10.1007/978-1-4684-5823-7_53

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Article

Monoclonal antibody-selected variants of MHV-4 contain substitutions and deletions in the E2 spike glycoprotein.

Advances in experimental medicine and biology - 1 Jan 1990

Gallagher T M, Buchmeier M J

Abstract excerpt

Selection and analysis of MHV-4 (strain JHM) variants resistant to E2-specific neutralizing MAbs was performed. Two types of variation in the E2 spike glycoprotein were found. From minimally passaged stocks of MHV-4, putative point mutants were obtained. These mutants were resistant only to the MAb used to select them. In contrast, multiply passaged stocks were found to harbor variants uniformly resistant to two...

Topics

Animals
Antibodies, Monoclonal
Brain
Cell Line
Chromosome Deletion
Genes, Viral
Genetic Variation
Membrane Glycoproteins
Mice
Mice, Inbred BALB C
Murine hepatitis virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neutralization Tests

RNA, Messenger

RNA, Viral

Spike Glycoprotein, Coronavirus

Transfection

Viral Envelope Proteins

Source

Open in PubMed

Identifiers

PMID: 1966428
DOI: 10.1007/978-1-4684-5823-7_53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1966428-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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