Gestational exposure to the AhR agonist 2,3,7,8‐tetrachlorodibenzo‐<i>p</i>‐dioxin induces BRCA‐1 promoter hypermethylation and reduces BRCA‐1 expression in mammary tissue of rat offspring: Preventive effects of resveratrol

Abstract excerpt

Studies with murine models suggest that maternal exposure to aromatic hydrocarbon receptor (AhR) agonists may impair mammary gland differentiation and increase the susceptibility to mammary carcinogenesis in offspring. However, the molecular mechanisms responsible for these perturbations remain largely unknown. Previously, we reported that the AhR agonists 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced CpG...

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