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Article

Myeloperoxidase promoter polymorphism -463G is associated with more severe clinical expression of cystic fibrosis pulmonary disease.

Mediators of inflammation - 1 Jan 2006

Reynolds Wanda F, Sermet-Gaudelus Isabelle, Gausson Valérie, Feuillet Marie-Noëlle, Bonnefont Jean-Paul, Lenoir Gérard, Descamps-Latscha Béatrice, Witko-Sarsat Véronique

Abstract excerpt

The severity of cystic fibrosis (CF) pulmonary disease is not directly related to CFTR genotype but depends upon several parameters, including neutrophil-dominated inflammation. Identification of agents modulating inflammation constitutes a relevant goal. Myeloperoxidase (MPO) is involved in both microbicidal and proinflammatory neutrophil activities. The aim of this study was to evaluate whether the -463GA MPO...

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Share to Cystic Fibrosis
Share to Cystic Fibrosis Transmembrane Conductance Regulator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Peroxidase

Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Share to Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 16883063
DOI: 10.1155/MI/2006/36735
PMCID: PMC1592586

Genes

MPO
CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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