Article
Diversification of HIV-1 strains after infection from a unique source.
AIDS research and human retroviruses - 1 Feb 1993
Kasper P, Kaiser R, Kleim J P, Oldenburg J, Brackmann H H, Rockstroh J, Schneweis K E
Abstract excerpt
In 1990, 7 hemophilia B patients were infected with human immunodeficiency virus type 1 (HIV-1) after exposure to a single common lot of clotting factor. The hypervariable regions V1 and V2 of the proviral env gene from the patients shared a homology between 97.5% and 100% at the time of seroconversion. To determine the in vivo diversification of these epidemiologically closely related virus strains, the patients...
Topics
- Amino Acid Sequence
- Base Sequence
- Blood Coagulation Factors
- DNA, Viral
- Drug Contamination
- Genes, env
- Genetic Variation
- HIV Infections
- HIV-1
- Hemophilia B
- Humans
- Sequence Homology, Amino Acid
- Sequence Homology, Nucleic Acid