Article
Restriction fragment length polymorphism (RFLP) heterogeneity of HLA-DQ beta genes associated with DNA fragment identical to the DR1-beta DNA structure.
Disease markers - 1 Jan 2000
Redford A, Magalong D, Onohara-Toyoda M, Tyan D, Riley W J, Maclaren N K, Rotter J I, Toyoda H
Abstract excerpt
Restriction fragment length polymorphism (RFLP) analyses of DR1 positive peripheral blood leukocytes DNA was carried out. The Taq I digested DNA was hybridized with cDNA probes for HLA-DR and -DQ beta genes. The DR probe detected fragments commonly observed in the DR1 specificity, whereas a new DQ-beta fragment was detected in some DR1 haplotypes when the DQ-beta probe was used. This fragment had an RFLP pattern...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
