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Article

Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility.

Schizophrenia research - 1 Oct 2006

Glaser Beate, Moskvina Valentina, Kirov George, Murphy Kieran C, Williams Hywel, Williams Nigel, Owen Michael J, O'Donovan Michael C

Abstract excerpt

Synergistic interaction between genes on chromosome 22q11 recently has been proposed as a possible mechanism which could confer increased risk for schizophrenia. Based on this hypothesis, our study aimed to explore main, cis- and trans-interacting effects of three candidate genes on 22q11, ProDH, COMT and ZDHHC8. We selected four putative risk variants, residing within these genes, ProDH 1945, ProDH 2026, COMT...

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Source

Identifiers

PMID: 16860541
DOI: 10.1016/j.schres.2006.05.024

Genes

COMT
ZDHHC8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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