Article
Epidermal growth factor receptor mutation testing in the care of lung cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2006
Sequist Lecia V, Joshi Victoria A, Jänne Pasi A, Bell Daphne W, Fidias Panos, Lindeman Neal I, Louis David N, Lee Jeffrey C, Mark Eugene J, Longtine Janina, Verlander Peter, Kucherlapati Raju, Meyerson Matthew, Haber Daniel A, Johnson Bruce E, Lynch Thomas J
Abstract excerpt
As the literature about epidermal growth factor receptor (EGFR) mutations grows and screening for mutations becomes increasingly integrated into clinical care, it is important to examine how best to do somatic mutational analyses and how best to use the test results in clinical decision making. We began offering mutation screening by comprehensive direct sequence analysis of exons 18 to 24 of the tyrosine kinase...
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