Article
Investigation of viral escape mutations within HCV p7 during treatment with amantadine in patients with chronic hepatitis C.
Antiviral therapy - 1 Jan 2013
Vermehren Annika, Welsch Christoph, Elsler Ulrike, Vermehren Johannes, Herrmann Eva, Sarrazin Christoph, von Wagner Michael, Susser Simone, Hofmann Wolf Peter, Kronenberger Bernd, Zeuzem Stefan, Mihm Ulrike
Abstract excerpt
BACKGROUND: Combination of several direct-acting antiviral agents will be necessary to overcome viral resistance in interferon-free treatment regimens for chronic HCV infection. HCV p7 inhibitors may be part of such combination regimens. Understanding why amantadine, despite showing inhibition of HCV p7 in vitro, appears ineffective in clinical trials, may help in the design of novel HCV p7 inhibitors. So far it...
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