Article
[Allelic and haplotypic diversity of HLA-A, -B, -C, and -DRB1 genes in Koreans defined by high-resolution DNA typing].
The Korean journal of laboratory medicine - 1 Dec 2010
Chung Hye Yoon, Yoon Jung Ah, Han Bok Youn, Song Eun Yung, Park Myoung Hee
Abstract excerpt
BACKGROUND: In this study, we used high-resolution DNA typing to investigate the distribution of HLA alleles and haplotypes in Koreans. METHODS: HLA-A, -B, -C, and -DRB1 alleles were genotyped at the allelic (4-digit) level in 474 healthy Koreans. HLA genotyping was performed in two steps. Initially, serologic typing or generic-level DNA typing was performed using the PCR-sequence-specific oligonucleotide method,...
Topics
- Alleles
- Asian People
- DNA Fingerprinting
- Gene Frequency
- Genetic Variation
- Genotype
- HLA-A Antigens
- HLA-B Antigens
- HLA-C Antigens
- HLA-DR Antigens
- HLA-DRB1 Chains
