Article
[Relationship between HLA D region gene and primary Sjögren's syndrome].
Zhonghua yi xue za zhi - 1 Oct 1991
Fei H, Scharf S, Erlich H, Peebles C, Tan E, Fox R
Abstract excerpt
Primary Sjögren's syndrome is characterized by lymphocytic infiltration of the salivary and lacrimal glands and by autoantibody production. In order to identify the genetic factors that play a role in the pathogenesis and to predict the progress of the disease we used the restriction fragment length polymorphism and polymerase chain reaction method to detect the polymorphism of HLA-DRB1, DRB3, DQA and DQB genes...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Child
- Female
- HLA-D Antigens
- HLA-DQ Antigens
- HLA-DR3 Antigen
- Humans
- Male
- Middle Aged
- Oligonucleotides