Article
Autosomal dominant polycystic kidney disease--in vitro culture of cyst-lining epithelial cells.
Virchows Archiv. B, Cell pathology including molecular pathology - 1 Jan 1991
Klingel R, Störkel S, Dippold W, Rumpelt H J, Moll R, Köhler H, Meyer zum Büschenfelde K H
Abstract excerpt
The major form of autosomal dominant polycystic kidney disease (ADPKD) in humans is linked to the PKD1 gene on chromosome 16p. The identity of the gene and the underlying pathogenetic mechanisms are not yet defined. Cyst-lining epithelial cells derived from a polycystic kidney were successfully g...
Topics
- Antibodies, Monoclonal
- Blotting, Northern
- Cells, Cultured
- Chromosomes, Human, Pair 16
- Epithelium
- Female
- Genetic Markers
- HLA-A Antigens
- HLA-B Antigens
- HLA-C Antigens
- Humans
- Immunohistochemistry
- Microscopy, Electron
- Middle Aged
- Pedigree
- Phenotype
- Polycystic Kidney, Autosomal Dominant