Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mispolarization of desmosomal proteins and altered intercellular adhesion in autosomal dominant polycystic kidney disease

9 Feb 2005

Abstract excerpt

Polycystin-1, the product of the major gene mutated in autosomal dominant polycystic kidney disease (ADPKD), has been shown to associate with multiple epithelial cell junctions. Our hypothesis is that polycystin-1 is an important protein for the initial establishment of cell-cell junctions and maturation of the cell and that polycystin-1 localization is dependent on the degree of cell polarization. Using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomedical Research and Pathophysiology
Share to Genetic and Kidney Cyst Diseases
Share to Renal and related cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15701820
DOI: 10.1152/ajprenal.00008.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mispolarization of desmosomal proteins and altered intercellular adhesion in autosomal dominant polycystic kidney diseasePMID 15701820Read ↗

Impaired formation of desmosomal junctions in ADPKD epithelia.Semantic proximity Read ↗

Compromised Cytoarchitecture and Polarized Trafficking in Autosomal Dominant Polycystic Kidney Disease CellsSemantic proximity Read ↗

Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion.Semantic proximity Read ↗

Homophilic and heterophilic polycystin 1 interactions regulate E-cadherin recruitment and junction assembly in MDCK cellsSemantic proximity Read ↗

Protein exchange is reduced in calcium-independent epithelial junctions.Semantic proximity Read ↗

Role of the polycystins as mechanosensors of extracellular stiffness.Semantic proximity Read ↗

Extracellularly truncated desmoglein 1 compromises desmosomes in MDCK cells.Semantic proximity Read ↗

Desmoglein-3 acts as a pro-survival protein by suppressing reactive oxygen species and doming whilst augmenting the tight junctions in MDCK cells.Semantic proximity Read ↗

Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells.Semantic proximity Read ↗

Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1Semantic proximity Read ↗

Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysisSemantic proximity Read ↗

Functional analysis of desmoplakin domains: specification of the interaction with keratin versus vimentin intermediate filament networks.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.