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Article

Impaired formation of desmosomal junctions in ADPKD epithelia.

Histochemistry and cell biology - 1 Dec 2005

Russo Ryan J, Husson Hervé, Joly Dominique, Bukanov Nikolay O, Patey Natacha, Knebelmann Bertrand, Ibraghimov-Beskrovnaya Oxana

Abstract excerpt

Mutations in polycystin-1 (PC-1) are responsible for autosomal dominant polycystic kidney disease (ADPKD), characterized by formation of fluid-filled tubular cysts. The PC-1 is a multifunctional protein essential for tubular differentiation and maturation found in desmosomal junctions of epithelial cells where its primary function is to mediate cell-cell adhesion. To address the impact of mutated PC-1 on...

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Identifiers

PMID: 16187067
DOI: 10.1007/s00418-005-0055-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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