Vaccination and the dynamics of immune evasion

Abstract excerpt

Vaccines exert strong selective pressures on pathogens, favouring the spread of antigenic variants. We propose a simple mathematical model to investigate the dynamics of a novel pathogenic strain that emerges in a population where a previous strain is maintained at low endemic level by a vaccine. We compare three methods to assess the ability of the novel strain to invade and persist: algebraic rate of invasion;...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to COVID-19 epidemiological studies
• Share to Evolution and Genetic Dynamics
• Share to Mathematical and Theoretical Epidemiology and Ecology Models