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Article

Short-chain fatty acids induce γ-globin gene expression by displacement of a HDAC3-NCoR repressor complex

19 Jul 2006

Abstract excerpt

High-level induction of fetal (gamma) globin gene expression for therapy of beta-hemoglobinopathies likely requires local chromatin modification and dissociation of repressor complexes for gamma-globin promoter activation. A novel gamma-globin-inducing short-chain fatty acid derivative (SCFAD), RB7, which was identified through computational modeling, produced a 6-fold induction in a reporter assay that detects...

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Share to Cancer-related gene regulation
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PMID: 16849648
DOI: 10.1182/blood-2005-12-010934

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