Article
Inactivation of HDAC 1 or HDAC 2 induces gamma globin expression without altering cell cycle or proliferation
24 Mar 2015
Abstract excerpt
Other than hydroxyurea, no pharmacologic agents are clinically available for fetal hemoglobin (HbF) induction in sickle cell disease (SCD). An optimal candidate would induce HbF without causing cell cycle inhibition and would act independently of hydroxyurea in order to yield additional HbF induction when combined. We explored whether inhibition of histone deacetylase (HDAC) 1 or HDAC2 could achieve these goals....
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