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Article

SIRT1 activates the expression of fetal hemoglobin genes

4 Aug 2017

Abstract excerpt

) levels ameliorate the clinical manifestations of sickle cell disease and β thalassemia. The mechanisms that repress HbF expression and silence γ-globin genes in adults are incompletely characterized and only a single HbF inducer, hydroxyurea, is approved for treatment, and only in patients with sickle cell disease. We identified SIRT1, a protein deacetylase, as a new inducer of γ-globin. SIRT1 knockdown...

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PMID: 28776729
DOI: 10.1002/ajh.24879

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