Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GATA5 interacts with GATA4 and GATA6 in outflow tract development.

Developmental biology - 15 Oct 2011

Laforest Brigitte, Nemer Mona

Abstract excerpt

Members of the GATA family of transcription factors are critical regulators of heart development and mutations in 2 of them, GATA4 and GATA6 are associated with outflow tract and septal defects in human. The heart expresses 3 GATA factors, GATA4, 5 and 6 in a partially overlapping pattern. Here, we report that compound Gata4/Gata5 and Gata5/Gata6 mutants die embryonically or perinatally due to severe congenital...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic Valve Stenosis
Share to Fetal Heart
Share to GATA4 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GATA6 Transcription Factor

Share to Gene Expression Regulation, Developmental

Share to Heart Defects, Congenital

Share to Heart Septal Defects, Ventricular

Share to Mice, Knockout

Source

Identifiers

PMID: 21839733
DOI: 10.1016/j.ydbio.2011.07.037

Genes

GATA4
GATA5
GATA6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GATA5 interacts with GATA4 and GATA6 in outflow tract development.PMID 21839733Read ↗

Gata4 and Gata5 Cooperatively Regulate Cardiac Myocyte Proliferation in MiceSemantic proximity Read ↗

Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development.Semantic proximity Read ↗

From embryogenesis to adulthood: Critical role for GATA factors in heart development and functionSemantic proximity Read ↗

Specificity, redundancy and dosage thresholds among gata4/5/6 genes during zebrafish cardiogenesis.Semantic proximity Read ↗

Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo.Semantic proximity Read ↗

Potential roles of GATA binding protein 5 in cardiovascular diseases.Semantic proximity Read ↗

A threshold of GATA4 and GATA6 expression is required for cardiovascular development.Semantic proximity Read ↗

GATA 5 mutation homozygosity linked to a double outlet right ventricle phenotype in a Lebanese patientSemantic proximity Read ↗

Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septationSemantic proximity Read ↗

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5.Semantic proximity Read ↗

GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesisSemantic proximity Read ↗

Gata5 and Gata6 are functionally redundant in zebrafish for specification of cardiomyocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.