A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure.

doi:10.1073/pnas.0509937103

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Article

A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jul 2006

Liggett Stephen B, Mialet-Perez Jeanne, Thaneemit-Chen Surai, Weber Stewart A, Greene Scott M, Hodne Danielle, Nelson Bradley, Morrison Jennifer, Domanski Michael J, Wagoner Lynne E, Abraham William T, Anderson Jeffrey L, Carlquist John F, Krause-Steinrauf Heidi J, Lazzeroni Laura C, Port J David, Lavori Philip W, Bristow Michael R

Abstract excerpt

Heterogeneity of heart failure (HF) phenotypes indicates contributions from underlying common polymorphisms. We considered polymorphisms in the beta(1)-adrenergic receptor (beta(1)AR), a beta-blocker target, as candidate pharmacogenomic loci. Transfected cells, genotyped human nonfailing and failing ventricles, and a clinical trial were used to ascertain phenotype and mechanism. In nonfailing and failing isolated...

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PMID: 16844790
DOI: 10.1073/pnas.0509937103
PMCID: PMC1523317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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