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β<sub>1</sub>- and β<sub>2</sub>-adrenergic Receptor Haplotypes Regulate Therapeutic Responses to Placebo and the Biased Ligand β-blocker Bucindolol

2025-08-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> ADRB1 and ADRB2, encoding cardiac myocyte β 1 - and β 2 -adrenergic receptors (ARs) that mediate pathologic myocardial remodeling in response to chronically increased signaling, contain N-terminus haplotype variants capable of influencing agonist- or biased ligand-induced receptor internalization that uncouples canonical signaling and initiates EGFR/ERK1/2 cardioprotection....

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Literature Corpus work
b7080283-eae4-5e0e-b306-4bf2643d73cf
DOI
10.1101/2025.08.22.25333921
Open publication

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β<sub>1</sub>- and β<sub>2</sub>-adrenergic Receptor Haplotypes Regulate Therapeutic Responses to Placebo and the Biased Ligand β-blocker BucindololDOI 10.1101/2025.08.22.25333921
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