Article
A chick wingless mutation causes abnormality in maintenance of Fgf8 expression in the wing apical ridge, resulting in loss of the dorsoventral boundary.
Mechanisms of development - 1 Feb 1997
Ohuchi H, Shibusawa M, Nakagawa T, Ohata T, Yoshioka H, Hirai Y, Nohno T, Noji S, Kondo N
Abstract excerpt
We analyzed a Japanese chick wingless mutant (Jwg) to know a molecular mechanism underlying wing development. We observed expression patterns of eleven marker genes to characterize the mutant. Expressions of dorsoventral (DV) and mesenchymal marker genes were intact in nascent Jwg limb buds. However, expression of Fgf8, a marker gene for the apical ectodermal ridge (AER), was delayed and shortly disappeared in...
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