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Article

Cigarette smoke induces cellular senescence.

American journal of respiratory cell and molecular biology - 1 Dec 2006

Nyunoya Toru, Monick Martha M, Klingelhutz Aloysius, Yarovinsky Timur O, Cagley Jeffrey R, Hunninghake Gary W

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States, and cigarette smoking is the major risk factor for COPD. Fibroblasts play an important role in repair and lung homeostasis. Recent studies have demonstrated a reduced growth rate for lung fibroblasts in patients with COPD. In this study we examined the effect of cigarette smoke extract (CSE) on fibroblast...

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PMID: 16840774
DOI: 10.1165/rcmb.2006-0169OC
PMCID: PMC2643295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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