Protein–protein interactions in the mammalian brain

Abstract excerpt

Recent genome-wide high-throughput (HTS) analyses of protein-protein interactions (PPIs) provide molecular-based information to uncover functions of cells and tissues, such as those of the mammalian brain. However, the HTS PPI data contain much false-negatives and false-positives, which should be primarily addressed in experiments. Integrating PPI data sets with other genome-wide data, such as expression profiles...

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