Article
Finnish Parkinson's disease study integrating protein-protein interaction network data with exome sequencing analysis.
Scientific reports - 11 Dec 2019
Siitonen Ari, Kytövuori Laura, Nalls Mike A, Gibbs Raphael, Hernandez Dena G, Ylikotila Pauli, Peltonen Markku, Singleton Andrew B, Majamaa Kari
Abstract excerpt
Variants associated with Parkinson's disease (PD) have generally a small effect size and, therefore, large sample sizes or targeted analyses are required to detect significant associations in a whole exome sequencing (WES) study. Here, we used protein-protein interaction (PPI) information on 36 genes with established or suggested associations with PD to target the analysis of the WES data. We performed an...
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