Article
Genetic polymorphisms at the human liver/islet glucose transporter (GLUT2) gene locus in Caucasian and West Indian subjects with type 2 (non-insulin-dependent) diabetes mellitus.
Biochimica et biophysica acta - 21 Nov 1991
Li S R, Alcolado J C, Stocks J, Baroni M G, Oelbaum R S, Galton D J
Abstract excerpt
The liver/islet glucose transporter (GLUT2) is mainly expressed in the hepatocytes of the liver and the beta-cells of the pancreatic islets and a defect in this transporter could lead to diabetic phenotypes, such as relative hypoinsulinaemia and reduced uptake and metabolism of glucose in the liv...
Topics
- Aged
- Alleles
- Deoxyribonucleases, Type II Site-Specific
- Diabetes Mellitus, Type 2
- Genetic Linkage
- Genotype
- Glucose
- Haplotypes
- Humans
- Islets of Langerhans
- Liver
- London
- Middle Aged
- Monosaccharide Transport Proteins
- Polymorphism, Restriction Fragment Length