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Article

Differential mapping of the amino acids mediating agonist and antagonist coordination with the human thromboxane A2 receptor protein.

The Journal of biological chemistry - 15 Sept 2006

Khasawneh Fadi T, Huang Jin-Sheng, Turek Joseph W, Le Breton Guy C

Abstract excerpt

Despite the well documented involvement of thromboxane A(2) receptor (TPR) signaling in the pathogenesis of thrombotic diseases, there are currently no rationally designed antagonists available for clinical use. To a large extent, this derives from a lack of knowledge regarding the topography of the TPR ligand binding pocket. On this basis, the purpose of the current study was to identify the specific amino acid...

Topics

Amino Acid Sequence
Amino Acids
Aspartic Acid
Calcium
Cell Line
Dose-Response Relationship, Drug
Humans
Ligands
Molecular Sequence Data
Mutation
Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Structure, Tertiary

Receptors, Thromboxane A2, Prostaglandin H2

Source

Identifiers

PMID: 16837469
DOI: 10.1074/jbc.M507469200

Genes

TPR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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