Article
Potency of carbapenems for the prevention of carbapenem-resistant mutants of Pseudomonas aeruginosa: the high potency of a new carbapenem doripenem.
The Journal of antibiotics - 1 Apr 2006
Sakyo Shihomi, Tomita Haruyoshi, Tanimoto Koichi, Fujimoto Shuhei, Ike Yasuyoshi
Abstract excerpt
The potencies of the carbapenems; doripenem (DRPM), meropenem (MEPM) and imipenem (IPM) in preventing the emergence of carbapenem-resistant mutants were examined in Pseudomonas aeruginosa strains. The carbapenems predominantly selected carbapenem-resistant mutants or carbapenem mutants with reduced susceptibilities that were specifically resistant to carbapenems and had arisen as a result of the reduced level of...
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