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Article

Alternative mutations of a positively selected residue elicit gain or loss of functionalities in enzyme evolution.

Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2006

Norrgård Malena A, Ivarsson Ylva, Tars Kaspars, Mannervik Bengt

Abstract excerpt

All molecular species in an organism are connected physically and functionally to other molecules. In evolving systems, it is not obvious to what extent functional properties of a protein can change to selective advantage and leave intact favorable traits previously acquired. This uncertainty has particular significance in the evolution of novel pathways for detoxication, because an organism challenged with new...

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Identifiers

PMID: 16549767
DOI: 10.1073/pnas.0600849103
PMCID: PMC1458763

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