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Article

Diagnosis of paroxysmal nocturnal hemoglobinuria by fluorescent clostridium septicum alpha toxin.

Journal of molecular microbiology and biotechnology - 1 Jan 2006

Shin Dong-Jun, Cho Duck, Kim Young Ran, Rhee Joon Haeng, Choy Hyon E, Lee Je-Jung, Hong Yeongjin

Abstract excerpt

Paroxysmal nocturnal hemoglobinuria (PNH), a hematopoietic stem cell disorder, is caused by the loss of glycosylphosphatidylinositol (GPI)-anchored proteins on the cell membrane. PNH can be simply diagnosed by flow cytometry using monoclonal antibodies against GPI-anchored proteins or fluorescent-tagged aerolysin, a bacterial toxin that binds GPI anchored proteins. Clostridium septicum alpha toxin is homologous...

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PMID: 16825787
DOI: 10.1159/000092816

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GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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