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Article

Advances in the creation of animal models of paroxysmal nocturnal hemoglobinuria.

Hematology (Amsterdam, Netherlands) - 1 Dec 2021

Chen Yingying, Rong Fu

Abstract excerpt

Paroxysmal nocturnal hemoglobinuria (PNH) is a disease caused by a phosphatidylinositol glycan anchor biosynthesis class A (PIG-A) mutation in hematopoietic stem cells. There are three theories about the possible mechanism of the pathogenesis of PNH: immune escape, anti-apoptotic mechanism, and secondary gene mutation. There has been little gain in the knowledge regarding its pathogenesis during the last decade...

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Identifiers

PMID: 34238137
DOI: 10.1080/16078454.2021.1945244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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