The O-antigen affects replication of Salmonella enterica serovar Typhimurium in murine macrophage-like J774-A.1 cells through modulation of host cell nitric oxide production.

Abstract excerpt

O-antigen-proficient and defined O-antigen-deficient mutants of Salmonella enterica serovar Typhimurium were compared for intracellular replication and induction of nitric oxide (NO) expression in the murine macrophage-like cell line J774-A.1. While O-antigen-proficient bacteria replicated and provoked induction of host cell NO synthesis to expected levels, DeltawaaK, DeltawaaL and DeltawaaKL mutants displayed...

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