An In Vitro Co-culture Mouse Model Demonstrates Efficient Vaccine-Mediated Control of Francisella tularensis SCHU S4 and Identifies Nitric Oxide as a Predictor of Efficacy

Abstract excerpt

Francisella tularensis is a highly virulent intracellular bacterium and cell-mediated immunity is critical for protection, but mechanisms of protection against highly virulent variants, such as the prototypic strain F. tularensis strain SCHU S4, are poorly understood. To this end, we established a co-culture system, based on splenocytes from naïve or immunized mice and in vitro infected bone marrow-derived...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bacillus and Francisella bacterial research
• Share to Bacterial Genetics and Biotechnology
• Share to SARS-CoV-2 and COVID-19 Research