Article
A lethal role for lipid A in Salmonella infections.
Molecular microbiology - 1 Jul 1998
Khan S A, Everest P, Servos S, Foxwell N, Zähringer U, Brade H, Rietschel E T, Dougan G, Charles I G, Maskell D J
Abstract excerpt
Salmonella infections in naturally susceptible mice grow rapidly, with death occurring only after bacterial numbers in vivo have reached a high threshold level, commonly called the lethal load. Despite much speculation, no direct evidence has been available to substantiate a role for any candidat...
Topics
- Acyltransferases
- Animals
- Escherichia coli Proteins
- Interleukin-1
- Lipid A
- Mice
- Mice, Inbred BALB C
- Mutation
- Nitric Oxide Synthase
- Nitric Oxide Synthase Type II
- Phenotype
- Salmonella Infections, Animal
- Salmonella typhimurium
- Tumor Necrosis Factor-alpha
- Virulence