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Salmonella typhimurium-induced M1 macrophage polarization is dependent on the bacterial O antigen.

World journal of microbiology & biotechnology - 1 Feb 2016

Luo Fengling, Sun Xiaoming, Qu Zhen, Zhang Xiaolian

Abstract excerpt

Recently, macrophages were shown to be capable of differentiating toward two phenotypes after antigen stimulation: a classically activated (M1) or an alternatively activated phenotype (M2). To investigate the effect of Salmonella enteric serovar typhimurium (S. typhimurium) on macrophage differentiation, we compared macrophage phenotypes after infection of murine bone marrow-derived macrophages with wild-type S....

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PMID: 26745982
DOI: 10.1007/s11274-015-1978-z

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