Article
The human immunoglobulin kappa locus: pseudogenes, unique and repetitive sequences.
Biological chemistry Hoppe-Seyler - 1 Mar 1994
Schäble K, Thiebe R, Flügel A, Meindl A, Zachau H G
Abstract excerpt
The human kappa locus contains 25 pseudogenes. After seven of them were described earlier the structures of the remaining 18 are reported now, thus completing the description of all human V kappa genes and pseudogenes. Most of the pseudogenes carry several defects each. Alignments of the pseudogene sequences and comparison with the consensus sequences of the potentially functional V kappa genes indicate that, on...
Topics
- Amino Acid Sequence
- Base Sequence
- Cloning, Molecular
- DNA
- Electrophoresis, Polyacrylamide Gel
- Genes
- Humans
- Immunoglobulin kappa-Chains
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization