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Article

The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease.

The Journal of biological chemistry - 30 Nov 2001

Chai Y, Wu L, Griffin J D, Paulson H L

Abstract excerpt

Intracellular inclusions are a unifying feature of polyglutamine (polyQ) neurodegenerative diseases, yet each polyQ disease displays a unique pattern of neuronal degeneration. This implies that the protein context of expanded polyQ plays an important role in establishing selective neurotoxicity. Here, in studies of the spinocerebellar ataxia type 3 disease protein ataxin-3, we demonstrate that the protein...

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PMID: 11572863
DOI: 10.1074/jbc.M106575200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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