Article
Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms.
Molecular cell - 7 Jul 2006
van Drogen Frank, Sangfelt Olle, Malyukova Aljona, Matskova Ludmila, Yeh Elizabeth, Means Anthony R, Reed Steven I
Abstract excerpt
Cyclin E, an activator of cyclin-dependent kinase 2 (Cdk2), is targeted for proteasomal degradation by phosphorylation-dependent multiubiquitylation via the ubiquitin ligase SCF(hCdc4). SCF ubiquitin ligases are composed of a core of conserved subunits and one variable subunit (an F box protein) involved in substrate recognition. We show here that multiubiquitylation of cyclin E requires the sequential function...
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