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Article

Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer.

Cancer cell - 8 Jul 2008

Barbash Olena, Zamfirova Petia, Lin Douglas I, Chen Xiangmei, Yang Ke, Nakagawa Hiroshi, Lu Fengmin, Rustgi Anil K, Diehl J Alan

Abstract excerpt

SCF(Fbx4) was recently identified as the E3 ligase for cyclin D1. We now describe cell-cycle-dependent phosphorylation and dimerization of Fbx4 that is regulated by GSK3beta and is defective in human cancer. We present data demonstrating that a pathway involving Ras-Akt-GSK3beta controls the temp...

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Identifiers

PMID: 18598945
DOI: 10.1016/j.ccr.2008.05.017
PMCID: PMC2597358

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18598945-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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