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Article

Fitness cost of chromosomal drug resistance-conferring mutations.

Antimicrobial agents and chemotherapy - 1 May 2002

Sander Peter, Springer Burkhard, Prammananan Therdsak, Sturmfels Antje, Kappler Martin, Pletschette Michel, Böttger Erik C

Abstract excerpt

To study the cost of chromosomal drug resistance mutations to bacteria, we investigated the fitness cost of mutations that confer resistance to different classes of antibiotics affecting bacterial protein synthesis (aminocyclitols, 2-deoxystreptamines, macrolides). We used a model system based on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11959546
DOI: 10.1128/AAC.46.5.1204-1211.2002
PMCID: PMC127173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11959546-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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