Article
Targeted sequencing analysis of ACVR2A gene identifies novel risk variants associated with preeclampsia.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians - 1 Sept 2019
Glotov Andrey S, Kazakov Sergey V, Vashukova Elena S, Pakin Vladimir S, Danilova Maria M, Nasykhova Yulia A, Masharsky Aleksey E, Mozgovaya Elena V, Eremeeva Dina R, Zainullina Marina S, Baranov Vladislav S
Abstract excerpt
Background: Preeclampsia (PE) is the most common complication of pregnancy that remains to be a major cause of maternal and fetal mortality. Prediction and early diagnosis of PE would allow for timely initiation of preventive therapy. According to recent studies of ACVR2A gene polymorphism is associated with PE, but it is still unclear whether these findings reflect specific pathogenetic mechanisms of this...
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