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Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1.

Journal of virology - 1 Jul 2006

Woo Patrick C Y, Lau Susanna K P, Yip Cyril C Y, Huang Yi, Tsoi Hoi-Wah, Chan Kwok-Hung, Yuen Kwok-Yung

Abstract excerpt

We sequenced and compared the complete genomes of 22 strains of coronavirus HKU1 (CoV HKU1) obtained from nasopharyngeal aspirates of patients with respiratory tract infections over a 2-year period. Phylogenetic analysis of 24 putative proteins and polypeptides showed that the 22 CoV HKU1 strains fell into three clusters (genotype A, 13 strains; genotype B, 3 strains and genotype C, 6 strains). However, different...

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PMID: 16809319
DOI: 10.1128/JVI.00509-06
PMCID: PMC1489027

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