Article
Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer).
The New England journal of medicine - 5 May 2005
Hampel Heather, Frankel Wendy L, Martin Edward, Arnold Mark, Khanduja Karamjit, Kuebler Philip, Nakagawa Hidewaki, Sotamaa Kaisa, Prior Thomas W, Westman Judith, Panescu Jenny, Fix Dan, Lockman Janet, Comeras Ilene, de la Chapelle Albert
Abstract excerpt
BACKGROUND: Germ-line mutations in the mismatch-repair genes MLH1, MSH2, MSH6, and PMS2 lead to the development of the Lynch syndrome (hereditary nonpolyposis colorectal cancer), conferring a strong susceptibility to cancer. We assessed the frequency of such mutations in patients with colorectal cancer and examined strategies for molecular screening to identify patients with the syndrome. METHODS: Patients with a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.