Article
Examining the role of common genetic variation in the gamma2 subunit of the GABA(A) receptor in epilepsy using tagging SNPs.
Epilepsy research - 1 Aug 2006
Kinirons Peter, Cavalleri Gianpiero L, Shahwan Amre, Wood Nicholas W, Goldstein David B, Sisodiya Sanjay M, Delanty Norman, Doherty Colin P
Abstract excerpt
INTRODUCTION: Mutations in the gamma2 subunit gene of the GABA(A) receptor, GABRG2, have been shown to cause generalised epilepsy syndromes in rare familial cases. Here we set out to examine whether common variation in GABRG2 predisposes to the development of common, complex forms of epilepsy in two large independent cohorts. METHODS: We have applied a tagging single nucleotide polymorphism (tSNP) technique...
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