Article
Association analysis of gamma 2 subunit of gamma- aminobutyric acid type A receptor polymorphisms with febrile seizures.
Pediatric research - 1 Jul 2003
Chou I-Ching, Peng Ching-Tien, Huang Chao-Ching, Tsai Jeffrey J P, Tsai Fuu-Jen, Tsai Chang-Hai
Abstract excerpt
An alternation of gamma-aminobutyric acid (GABA)-ergic neurotransmission has been implicated as an etiologic factor in epileptogenesis. Missense mutations in the GABRG2 gene, which encodes the gamma2 subunit of central nervous GABAA receptors, have recently been described in one family with childhood absence epilepsy and febrile seizures (FSs). FSs represent the majority of childhood seizures and have a genetic...
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